Job Description Summary The Neuroscience Department within BioMedical Research at Novartis Pharma AG in Basel, Switzerland, is searching for a motivated and experienced Research or Senior Scientist. This individual will assume a hands-on role within the in vivo neuroinflammation team and contribute to several research projects focused on the development of new therapies for neurodegenerative disorders, potentially helping improve the lives of millions of patients worldwide suffering neurodegenerative illnesses and conditions.The main focus will be on novel neuroimmune cell pathways to elucidate the mechanisms at the molecular, cellular and ex vivo/in vivo level.Joining our team you will independently but with close collaboration with the other members of the Neurosciences group plan, execute, document, analyze and interpret experiments.Job DescriptionYour responsibilities will include:Designing, conducting and protocolling independently in vivo studies with specific focus on neuroinflammatory pathwaysEstablishment of new in vivo models for neuroinflammatory/neurodegenerative diseasesPerforming and interpreting ex vivo analyses with emphasis on histology, biochemistry, FACS and molecular biologyDevelopment and execution of in vitro cellular assays for assessing inflammatory processesPresenting data and putting it in a complex contextSupporting general laboratory dutiesYour profile:University degree (MSc) or equivalent qualification, preferably in neuroscience, immunology, cell biology. *Please note that PhD candidates will not be considered for this position*Minimum 2-3 years relevant lab based work experience in an industrial or academic settingPrevious experience in neuroscience drug discovery area would be an advantage.Strong expertise in in vivo rodent work e.g. different routes of dosing, surgery, stereotactic brain injections, behavior, perfusion. Relevant animal experiment course available (e.g. LTK1)Experience in different histological methods, microscopy and image analysesExperience in RNA/DNA technologies and biochemistry, e.g. qPCR technologies, WesternblotGood knowledge of immunology and immunological methods such as flow cytometry, HTRF, ELISAGood knowledge in cell culture work, e.g. primary cells, iPSCsUsed to evaluating large datasets, strong documentation capabilities and interest to use new informatics analysis toolsEager to learn and combine new techniques and concepts, to present results within the lab, to use and apply literature data, to perform exploratory activities and to work independently and as a team memberScientific curiosity, initiative, commitment, flexibility and good organization skillsTrack record of successful collaborations, open communication with different stakeholders, strong team player and networkerExcellent oral and written EnglishAccessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message.Skills Desired
